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Additional information about this peptide:

CAS#: 153049-49-1
Solubility: Soluble in water, PBS and DMSO 1 mg/ml
Notes: D-Bhg = D-5H-Dibenzo[a,d]cycloheptene-5-acetic acid

Description:
ET Antagonist PD 145065 is used as an endothelin-A/endothelin-B (ETA/ETB) receptor antagonist. PD 145065 is also a growth factor that binds to G protein-couples receptors and serves as a useful model to study mitogenic signal transduction by vasoactive peptides.

References:
1. Kanagy, N.L. et al. (2001) “Role of Endothelin in Intermittent Hypoxia-Induced Hypertension” 37 (2 Pt 2): 511-5.
2. Bourque, S.L. et al (2012) “Role of endothelin-1 in the hyper-responsiveness to
nitrovasodilators following acute NOS inhibition” Br. J. Pharmacol. 165 (6): 1992-1999.
3. Dobrowolski, L. (2003) “Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin” Acta Physiol. Scand. 159 (1): 7-13.

Each peptide comes complete with the following information:

a QC summary sheet
two reverse phase HPLC profiles to verify purity
mass spectrometry to verify molecular weight
amino acid analysis to verify composition

We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.

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1.0 mg for $89.00

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ET Antagonist PD 145065