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ET Antagonist PD 145065

Sequence: 
Acetyl-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH
Molecular Weight: 
949.49
Catalog Number: 
331-18
Categories:
Cardiovascular, Neuropeptides & Hormones

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Additional information about this peptide:

CAS#: 153049-49-1
Solubility: Soluble in water, PBS and DMSO 1 mg/ml
Notes: D-Bhg = D-5H-Dibenzo[a,d]cycloheptene-5-acetic acid

Description:
ET Antagonist PD 145065 is used as an endothelin-A/endothelin-B (ETA/ETB) receptor antagonist. PD 145065 is also a growth factor that binds to G protein-couples receptors and serves as a useful model to study mitogenic signal transduction by vasoactive peptides.

References:
1. Kanagy, N.L. et al. (2001) “Role of Endothelin in Intermittent Hypoxia-Induced Hypertension” 37 (2 Pt 2): 511-5.
2. Bourque, S.L. et al (2012) “Role of endothelin-1 in the hyper-responsiveness to
nitrovasodilators following acute NOS inhibition” Br. J. Pharmacol. 165 (6): 1992-1999.
3. Dobrowolski, L. (2003) “Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin” Acta Physiol. Scand. 159 (1): 7-13.

Each peptide comes complete with the following information:
  • a QC summary sheet
  • two reverse phase HPLC profiles to verify purity
  • mass spectrometry to verify molecular weight
  • amino acid analysis to verify composition
We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.

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1.0 mg for $89.00
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