Endothelin-1 is one of three isoforms of human endothelin (ET-1). It is a potent vasoconstrictor that is expressed by many cell types, with the vascular endothelium being most prominent. Endothelin-1 is also produced by many tissues, including kidney, brain and lung among others. Antagonists of endothelin-1 receptors are used to treat pulmonary hypertension by inhibiting pulmonary vascular constriction thereby decreasing pulmonary vascular resistance.
Each peptide comes complete with the following information:
a QC summary sheet
two reverse phase HPLC profiles to verify purity
mass spectrometry to verify molecular weight
amino acid analysis to verify composition
We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.