Solubility: Soluble in water (1 mg/mL)
Notes: Disulfide bridges Cys1-Cys15 and Cys3-Cys11
Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. Endothelin-3 is an endogenous neuropeptide and potent vasoconstrictor. Endothelin-3 has been reported to attenuate thrombin-evoked aggregation of human platelets, acts as a potent stimulator of interleukin-6 production by endothelial cell lines, activates phospholipase C in fibroblasts expressing ETA receptors and induces the production of VEGF.
Each peptide comes complete with the following information:
a QC summary sheet
two reverse phase HPLC profiles to verify purity
mass spectrometry to verify molecular weight
amino acid analysis to verify composition
We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.