Notes: Also called Granzyme B substrate
Ac-IETD-pNA is a substrate for caspase-8 and granzyme B. Caspases are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Caspase-8 is an attractive therapeutic target for a variety of degenerative disorders. The absorbance maximum for the cleaved pNA is at 405 nm.
Each peptide comes complete with the following information:
a QC summary sheet
two reverse phase HPLC profiles to verify purity
mass spectrometry to verify molecular weight
amino acid analysis to verify composition
We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.