Calpain Inhibitor III is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) in addition to cathepsin B (Ki = 24 nM). Calpains are calcium-dependent cysteine proteases involved in a wide range of physiological processes. Calpain inhibitors can protect against necrotic neuronal death and, to a lesser extent, apoptotic death. Calpain inhibitors are useful tools for studying diseases, especially those involving neurodegeneration. Calpain Inhibitor III has been shown to inhibit neurofilament degradation in neurodegenerative diseases.
Each peptide comes complete with the following information:
a QC summary sheet
two reverse phase HPLC profiles to verify purity
mass spectrometry to verify molecular weight
amino acid analysis to verify composition
We use outside laboratories to provide the amino acid analysis and mass spectrometry. This third-party verification allows us to remain objective and has helped us achieve an excellent record of delivering top quality peptides since 1993.